Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process

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dc.contributor.authorStang, Antonia S.
dc.contributor.authorTrudeau, Melanie
dc.contributor.authorVanderkooi, Otto G.
dc.contributor.authorLee, Bonita E.
dc.contributor.authorChui, Linda
dc.contributor.authorPang, Xiao-Li
dc.contributor.authorAllen, Vanessa
dc.contributor.authorBurnham, Carey-Ann D.
dc.contributor.authorGoldfarb, David M.
dc.contributor.authorMacDonald, Judy
dc.contributor.authorParsons, Brendon
dc.contributor.authorPetrich, Astrid
dc.contributor.authorPollari, Frank
dc.contributor.authorTarr, Phillip I.
dc.contributor.authorTipples, Graham
dc.contributor.authorZhuo, Ran
dc.contributor.authorFreedman, Stephen B.
dc.date.accessioned2018-09-30T07:05:05Z
dc.date.available2018-09-30T07:05:05Z
dc.date.issued2018-09-27
dc.date.updated2018-09-30T07:05:05Z
dc.description.abstractBackground. We sought to develop diagnostic test guidance definitions for pediatric enteric infections to facilitate the interpretation of positive test results in the era of multianalyte molecular diagnostic test platforms. Methods. We employed a systematic, two-phase, modified Delphi consensus process consisting of three web-based surveys and an expert panel face-to-face meeting. In phase 1, we surveyed an advisory panel of North American experts to select pathogens requiring diagnostic test guidance definition development. In phase 2, we convened a 14-member expert panel to develop, refine, and select the final definitions through two web-based questionnaires interspersed with a face-to-face meeting. Both questionnaires asked panelists to rate the degree to which they agreed that if the definition is met the pathogen is likely to be causative of clinical illness. Results. The advisory panel survey identified 19 pathogens requiring definitions. In the expert panel premeeting survey, 13 of the 19 definitions evaluated were rated as being highly likely (“agree” or “strongly agree”) to be responsible for acute gastroenteritis symptoms by ≥67% of respondent panel members. The definitions for the remaining six pathogens (Aeromonas, Clostridium difficile, Edwardsiella, nonenteric adenovirus, astrovirus, and Entamoeba histolytica) were indeterminate. After the expert panel meeting, only two of the modified definitions, C. difficile and E. histolytica/dispar, failed to achieve the a priori specified threshold of ≥67% agreement. Conclusions. We developed diagnostic test guidance definitions to assist healthcare providers for 17 enteric pathogens. We identified two pathogens that require further research and definition development.
dc.description.versionPeer Reviewed
dc.identifier.citationAntonia S. Stang, Melanie Trudeau, Otto G. Vanderkooi, et al., “Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process,” Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 2018, Article ID 2589826, 11 pages, 2018. doi:10.1155/2018/2589826
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33059
dc.identifier.urihttp://dx.doi.org/10.1155/2018/2589826
dc.identifier.urihttp://hdl.handle.net/1880/108706
dc.language.rfc3066en
dc.rights.holderCopyright © 2018 Antonia S. Stang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleDiagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process
dc.typeJournal Article
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