Both candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon

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dc.contributor.authorPortanier, Elodie
dc.contributor.authorGarel, Mathieu
dc.contributor.authorDevillard, Sébastien
dc.contributor.authorMaillard, Daniel
dc.contributor.authorPoissant, Jocelyn
dc.contributor.authorGalan, Maxime
dc.contributor.authorBenabed, Slimania
dc.contributor.authorPoirel, Marie-Thérèse
dc.contributor.authorDuhayer, Jeanne
dc.contributor.authorItty, Christian
dc.contributor.authorBourgoin, Gilles
dc.date.accessioned2019-03-10T01:03:26Z
dc.date.available2019-03-10T01:03:26Z
dc.date.issued2019-03-05
dc.date.updated2019-03-10T01:03:26Z
dc.description.abstractAbstract Background Parasite infections can have substantial impacts on population dynamics and are accordingly a key challenge for wild population management. Here we studied genetic mechanisms driving parasite resistance in a large herbivore through a comprehensive approach combining measurements of neutral (16 microsatellites) and adaptive (MHC DRB1 exon 2) genetic diversity and two types of gastrointestinal parasites (nematodes and coccidia). Results While accounting for other extrinsic and intrinsic predictors known to impact parasite load, we show that both neutral genetic diversity and DRB1 are associated with resistance to gastrointestinal nematodes. Intermediate levels of multi-locus heterozygosity maximized nematodes resistance, suggesting that both in- and outbreeding depression might occur in the population. DRB1 heterozygosity and specific alleles effects were detected, suggesting the occurrence of heterozygote advantage, rare-allele effects and/or fluctuating selection. On the contrary, no association was detected between genetic diversity and resistance to coccidia, indicating that different parasite classes are impacted by different genetic drivers. Conclusions This study provides important insights for large herbivores and wild sheep pathogen management, and in particular suggests that factors likely to impact genetic diversity and allelic frequencies, including global changes, are also expected to impact parasite resistance.
dc.identifier.citationBMC Ecology. 2019 Mar 05;19(1):12
dc.identifier.doihttps://doi.org/10.1186/s12898-019-0228-x
dc.identifier.urihttp://hdl.handle.net/1880/110052
dc.language.rfc3066en
dc.rights.holderThe Author(s)
dc.titleBoth candidate gene and neutral genetic diversity correlate with parasite resistance in female Mediterranean mouflon
dc.typeJournal Article
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