A cell-permeant peptide corresponding to the cUBP domain of USP5 reverses inflammatory and neuropathic pain
Date
2016-01-01
Journal Title
Journal ISSN
Volume Title
Publisher
Sage Publishing
Abstract
Cav3.2 T-type calcium currents in primary afferents are enhanced in various painful pathological conditions, whereas inhibiting Cav3.2 activity or expression offers a strategy for combating the development of pain hypersensitivity. We have shown that Cav3.2 channel surface density is strongly regulated by the ubiquitination machinery and we identified the deubiquitinase USP5 as a Cav3.2 channel interacting protein and regulator of its cell surface expression. We also reported that USP5 is upregulated in chronic pain conditions. Conversely, preventing its binding to the channel in vivo mediates analgesia in inflammatory and neuropathic pain models.
Description
Keywords
T-type channels, Cav3.2, USP5, chronic pain, TAT-cUBP1-USP5 peptide, diabetic neuropathy, Complete Freund's Adjuvant
Citation
Garcia-Caballero, A., Gadotti, V. M., Chen, L., & Zamponi, G. W. (2016). A cell-permeant peptide corresponding to the cUBP domain of USP5 reverses inflammatory and neuropathic pain. Molecular Pain, 12. https://doi.org/10.1177/174480691664244