Postictal behavioural impairments are due to a severe prolonged hypoperfusion/ hypoxia event that is COX-2 dependent

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dc.contributor.authorFarrell, Jordan
dc.contributor.authorGaxiola-Valdez, Ismael
dc.contributor.authorWolff, Marshal
dc.contributor.authorDavid, Laurence
dc.contributor.authorDika, Haruna
dc.contributor.authorGeeraert, Bryce
dc.contributor.authorWang, X Rachel
dc.contributor.authorSingh, Shaily
dc.contributor.authorSpanswick, Simon
dc.contributor.authorDunn, Jeffrey F.
dc.contributor.authorAntle, Michael
dc.contributor.authorFederico, Paolo
dc.contributor.authorTeskey, G Campbell
dc.date.accessioned2017-03-13T22:00:33Z
dc.date.available2017-03-13T22:00:33Z
dc.date.issued2016-11-22
dc.description.abstractAbstract Seizures are often followed by sensory, cognitive or motor impairments during the postictal phase that show striking similarity to transient hypoxic/ischemic attacks. Here we show that seizures result in a severe hypoxic attack confined to the postictal period. We measured brain oxygenation in localized areas from freely-moving rodents and discovered a severe hypoxic event (pO2 < 10 mmHg) after the termination of seizures. This event lasted over an hour, is mediated by hypoperfusion, generalizes to people with epilepsy, and is attenuated by inhibiting cyclooxygenase-2 or L-type calcium channels. Using inhibitors of these targets we separated the seizure from the resulting severe hypoxia and show that structure specific postictal memory and behavioral impairments are the consequence of this severe hypoperfusion/hypoxic event. Thus, epilepsy is much more than a disease hallmarked by seizures, since the occurrence of postictal hypoperfusion/hypoxia results in a separate set of neurological consequences that are currently not being treated and are preventable.en_US
dc.description.grantingagencyCanadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canadaen_US
dc.description.refereedYesen_US
dc.identifier.citationFarrell JS1, Gaxiola-Valdez I1, Wolff MD1, David LS1, Dika HI1,2, Geeraert BL1, Rachel Wang X1, Singh S1, Spanswick SC1, Dunn JF1, Antle MC1, Federico P1, Teskey GC1. (2016). Postictal behavioural impairments are due to a severe prolonged hypoperfusion/hypoxia event that is COX-2 dependent. eLife 2016;5:e19352en_US
dc.identifier.doi10.7554/eLife.19352
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33525
dc.identifier.urihttp://hdl.handle.net/1880/51855
dc.language.isoenen_US
dc.publishereLife Sciences Publications Ltden_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentPsychologyen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectbehavioural dysfunctionen_US
dc.subjectepilepsyen_US
dc.subjecthumanen_US
dc.subjecthypoperfusionen_US
dc.subjecthypoxiaen_US
dc.subjectmouseen_US
dc.subjectneuroscienceen_US
dc.subjectraten_US
dc.subjectseizuresen_US
dc.titlePostictal behavioural impairments are due to a severe prolonged hypoperfusion/ hypoxia event that is COX-2 dependenten_US
dc.typejournal article
thesis.degree.disciplineRadiology / Physiology / Clinical Neurosciences
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