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Detection of reduced interhemispheric cortical communication during task execution in multiple sclerosis patients using functional near-infrared spectroscopy

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Author
Jimenez, Jon J
Yang, Runze
Nathoo, Nabeela
Varshney, Vishal P
Golestani, Ali-Mohammad
Metz, Luanne M
Dunn, Jeff F
Accessioned
2017-03-13T21:59:14Z
Available
2017-03-13T21:59:14Z
Issued
2014-07-08
Subject
coherence
demyelination
functional near-infrared spectroscopy
motor cortex
multiple sclerosis
near-infrared spectroscopy
Type
journal article
Metadata
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Abstract
Multiple sclerosis (MS) impairs brain activity through demyelination and loss of axons. Increased brain activity is accompanied by increases in microvascular hemoglobin oxygen saturation (oxygenation) and total hemoglobin, which can be measured using functional near-infrared spectroscopy (fNIRS). Due to the potentially reduced size and integrity of the white matter tracts within the corpus callosum, it may be expected that MS patients have reduced functional communication between the left and right sides of the brain; this could potentially be an indicator of disease progression. To assess interhemispheric communication in MS, we used fNIRS during a unilateral motor task and the resting state. The magnitude of the change in hemoglobin parameters in the motor cortex was significantly reduced in MS patients during the motor task relative to healthy control subjects. There was also a significant decrease in interhemispheric communication between the motor cortices (expressed as coherence) in MS patients compared to controls during the motor task, but not during the resting state. fNIRS assessment of interhemispheric coherence during task execution may be a useful marker in disorders with white matter damage or axonal loss, including MS.
Grantingagency
Multiple Sclerosis Society of Canada, Alberta endMS Regional Research and Training Centre of the endMS Research and Training Network, National Science and Engineering Research Council of Canada, Alberta Innovates-Health Solutions
Refereed
Yes
Citation
Jimenez et al. Detection of reduced interhemispheric cortical communication during task execution in multiple sclerosis patients using functional near-infrared spectroscopy. Journal of Biomedical Optics 19(7), 076008 (July 2014).
Corporate
University of Calgary
Department
Radiology
Faculty
Medicine
Institution
University of Calgary
Publisher
Society of Photo-optical Instrumentation Engineers
Doi
http://dx.doi.org/10.1117/1.JBO.19.7.076008.
http://dx.doi.org/10.11575/PRISM/33485
Uri
http://hdl.handle.net/1880/51853
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