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A Tale of Two Methods: Combining Near-Infrared Spectroscopy with MRI for Studies of Brain Oxygenation and Metabolism

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Author
Dunn, Jeffrey F.
Nathoo, Nabeela
Yang, Runze
Accessioned
2017-03-17T22:55:19Z
Available
2017-03-17T22:55:19Z
Issued
2014-03-22
Subject
MRI
near-infrared
brain
hypoxia
multimodel imaging
Type
Article
Metadata
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Abstract
Combining magnetic resonance imaging (MRI) with near-infrared spectroscopy (NIRS) leads to excellent synergies which can improve the interpretation of either method and can provide novel data with respect to measuring brain oxygenation and metabolism. MRI has good spatial resolution, can detect a range of physiological parameters and is sensitive to changes in deoxyhemoglobin content. NIRS has lower spatial resolution, but can detect, and with specific technologies, quantify, deoxyhemoglobin, oxyhemoglobin, total hemoglobin and cytochrome oxidase. This paper reviews the application of both methods, as a multimodal technology, for assessing changes in brain oxygenation that may occur with changes in functional activation state or metabolic rate. Examples of hypoxia and ischemia are shown. Data support the concept of reduced metabolic rate resulting from hypoxia/ischemia and that metabolic rate in brain is not close to oxygen limitation during normoxia. We show that multimodal MRI and NIRS can provide novel information for studies of brain metabolism.
Grantingagency
NSERC; CIHR; endMS; MS Society of Canada; AIHS
Refereed
Yes
Corporate
University of Calgary
Department
Radiology
Faculty
Medicine
Institution
University of Calgary
Publisher
Kluwer
Doi
http://dx.doi.org/10.1007/978-1-4939-0620-8_9
Uri
http://hdl.handle.net/1880/51881
Collections
  • Cumming School of Medicine Research & Publications

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