Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures

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dc.contributor.authorDesgagné-Penix, Isabel
dc.contributor.authorKhan, Morgan F.
dc.contributor.authorSchriemer, David C.
dc.contributor.authorCram, Dustin
dc.contributor.authorNowak, Jacek
dc.contributor.authorFacchini, Peter J.
dc.date.accessioned2017-06-01T20:41:38Z
dc.date.available2017-06-01T20:41:38Z
dc.date.issued2010-11-18
dc.description.abstractPapaver somniferum (opium poppy) is the source for several pharmaceutical benzylisoquinoline alkaloids including morphine, the codeine and sanguinarine. In response to treatment with a fungal elicitor, the biosynthesis and accumulation of sanguinarine is induced along with other plant defense responses in opium poppy cell cultures. The transcriptional induction of alkaloid metabolism in cultured cells provides an opportunity to identify components of this process via the integration of deep transcriptome and proteome databases generated using next-generation technologies.en_US
dc.description.refereedYes
dc.description.sponsorshipThis work was funded by a Natural Sciences and Engineering Research Council of Canada Strategic Project Grant to PJF. DCS holds the Canada Research Chair in Chemical Biology. PJF holds the Canada Research Chair in Plant Metabolic Processes Biotechnology.en_US
dc.identifier.citationDesgagné-Penix, I., Khan, M. F., Schriemer, D. C., Cram, D., Nowak, J., & Facchini, P. J. (2010). Integration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures. BMC Plant Biology, 10(1), 252-252. doi:10.1186/1471-2229-10-252en_US
dc.identifier.doi10.1186/1471-2229-10-252
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33801
dc.identifier.issn1471-2229en_US
dc.identifier.urihttp://hdl.handle.net/1880/52008
dc.language.isoenen_US
dc.publisherBMC Plant Biology
dc.publisher.departmentBiological Sciences
dc.publisher.facultySciences
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.urlhttps://bmcplantbiol.biomedcentral.com/en_US
dc.subjectBerberine Bridge Enzyme
dc.subjectPapaver-Somniferum
dc.subjectMolecular-Cloning
dc.subjectMorphine Biosynthesis
dc.subjectDihydrobenzophenanthridine Oxidase
dc.subjectNorcoclaurine Synthase
dc.subjectN-Methyltransferase
dc.subjectSuspension Cultures
dc.subjectGene Transcript
dc.subjectExpression
dc.titleIntegration of deep transcriptome and proteome analyses reveals the components of alkaloid metabolism in opium poppy cell cultures
dc.typejournal article
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