Mesolimbic dopamine and its neuromodulators in obesity and binge eating

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dc.contributor.authorNaef, Lindsay
dc.contributor.authorPitman, Kimberley A
dc.contributor.authorBorgland, Stephanie L
dc.date.accessioned2021-04-06T22:50:58Z
dc.date.available2021-04-06T22:50:58Z
dc.date.issued2015-12
dc.description.abstractObesity has reached epidemic prevalence, and much research has focused on homeostatic and nonhomeostatic mechanisms underlying overconsumption of food. Mesocorticolimbic circuitry, including dopamine neurons of the ventral tegmental area (VTA), is a key substrate for nonhomeostatic feeding. The goal of the present review is to compare changes in mesolimbic dopamine function in human obesity with diet-induced obesity in rodents. Additionally, we will review the literature to determine if dopamine signaling is altered with binge eating disorder in humans or binge eating modeled in rodents. Finally, we assess modulation of dopamine neurons by neuropeptides and peripheral peptidergic signals that occur with obesity or binge eating. We find that while decreased dopamine concentration is observed with obesity, there is inconsistency outside the human literature on the relationship between striatal D2 receptor expression and obesity. Finally, few studies have explored how orexigenic or anorexigenic peptides modulate dopamine neuronal activity or striatal dopamine in obese models. However, ghrelin modulation of dopamine neurons may be an important factor for driving binge feeding in rodents.en_US
dc.identifier.doihttp://dx.doi.org/10.1017/S1092852915000693en_US
dc.identifier.urihttp://hdl.handle.net/1880/113203
dc.language.isoengen_US
dc.subjectDiet-induced obesityen_US
dc.subjecthormonesen_US
dc.subjectmesolimbic dopamineen_US
dc.subjectneuropeptidesen_US
dc.subjectstriatumen_US
dc.subjectventral tegmental areaen_US
dc.titleMesolimbic dopamine and its neuromodulators in obesity and binge eatingen_US
dc.typejournal articleen_US
ucalgary.item.requestcopytrueen_US
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