Role of prions in neuroprotection and neurodegeneration: a mechanism involving glutamate receptors?

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dc.contributor.authorZamponi, Gerald W.
dc.contributor.authorStys, Peter K.
dc.date.accessioned2018-05-10T19:14:36Z
dc.date.available2018-05-10T19:14:36Z
dc.date.issued2009-12-01
dc.description.abstractThere is increasing evidence that cellular prion protein plays important roles in neurodegeneration and neuroprotection. One of the possible mechanism by which this may occur is a functional inhibition of ionotropic glutamate receptors, including N-Methyl-D-Aspartate (NMDA) receptors. Here we review recent evidence implicating a possible interplay between NMDA receptors and prions in the context of neurodegenerative disorders. Such is a functional link between NMDA receptors and normal prion protein, and therefore possibly between these receptors and pathological prion isoforms, raises interesting therapeutic possibilities for prion diseases.en_US
dc.identifier.citationZamponi, G. and Stys, P. (2009). Role of prions in neuroprotection and neurodegeneration. Prion, 3(4), 187-189.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/31911
dc.identifier.urihttp://hdl.handle.net/1880/106629
dc.language.isoenen_US
dc.publisherPrionen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleRole of prions in neuroprotection and neurodegeneration: a mechanism involving glutamate receptors?en_US
dc.typeunknown
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