Understanding disease processes in multiple sclerosis through magnetic resonance imaging studies in animal models
Date
2014-04-24
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
There are exciting new advances in multiple sclerosis (MS) resulting in a growing understanding of both
the complexity of the disorder and the relative involvement of grey matter, white matter and inflammation.
Increasing need for preclinical imaging is anticipated, as animal models provide insights into the pathophysiology
ofthe disease. Magnetic resonance (MR)is the key imaging tool used to diagnose and to monitor disease
progression in MS, and thus will be a cornerstone for future research. Although gadolinium-enhancing and T2
lesions on MRI have been useful for detecting MS pathology, they are not correlative of disability. Therefore,
new MRI methods are needed. Such methods require validation in animal models. The increasing necessity
for MRI of animal models makes it critical and timely to understand what research has been conducted in
this area and what potential there is for use of MRI in preclinical models of MS. Here, we provide a review
of MRI and magnetic resonance spectroscopy (MRS) studies that have been carried out in animal models of
MS that focus on pathology. We compare the MRI phenotypes of animals and patients and provide advice on
how best to use animal MR studies to increase our understanding of the linkages between MR and pathology
in patients. This review describes how MRI studies of animal models have been, and will continue to be, used
in the ongoing effort to understand MS.
Description
Keywords
Cuprizone, Experimental autoimmune encephalomyelitis, Lysolecithin, Magnetic resonance imaging, Multiple sclerosis, Theiler's murine encephalomyelitis virus
Citation
Nathoo N, Yong VW, Dunn JF. (2014). Understanding disease processes in multiple sclerosis through magnetic resonance imaging studies in animal models. Neuroimage Clin. 24;4:743-56.