Understanding disease processes in multiple sclerosis through magnetic resonance imaging studies in animal models

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dc.contributor.authorNathoo, Nabeela
dc.contributor.authorYong, V. Wee
dc.contributor.authorDunn, Jeffrey F.
dc.date.accessioned2017-03-13T22:00:00Z
dc.date.available2017-03-13T22:00:00Z
dc.date.issued2014-04-24
dc.description.abstractThere are exciting new advances in multiple sclerosis (MS) resulting in a growing understanding of both the complexity of the disorder and the relative involvement of grey matter, white matter and inflammation. Increasing need for preclinical imaging is anticipated, as animal models provide insights into the pathophysiology ofthe disease. Magnetic resonance (MR)is the key imaging tool used to diagnose and to monitor disease progression in MS, and thus will be a cornerstone for future research. Although gadolinium-enhancing and T2 lesions on MRI have been useful for detecting MS pathology, they are not correlative of disability. Therefore, new MRI methods are needed. Such methods require validation in animal models. The increasing necessity for MRI of animal models makes it critical and timely to understand what research has been conducted in this area and what potential there is for use of MRI in preclinical models of MS. Here, we provide a review of MRI and magnetic resonance spectroscopy (MRS) studies that have been carried out in animal models of MS that focus on pathology. We compare the MRI phenotypes of animals and patients and provide advice on how best to use animal MR studies to increase our understanding of the linkages between MR and pathology in patients. This review describes how MRI studies of animal models have been, and will continue to be, used in the ongoing effort to understand MS.en_US
dc.description.grantingagencyCanadian Institutes of Health Research, the Natural Sciences and Engineering Research Council of Canada, Alberta Innovates — Health Solutions, the Multiple Sclerosis Society of Canada, Alberta endMS Regional Research and Training Centre of the endMS Research and Training Networken_US
dc.description.refereedYesen_US
dc.identifier.citationNathoo N, Yong VW, Dunn JF. (2014). Understanding disease processes in multiple sclerosis through magnetic resonance imaging studies in animal models. Neuroimage Clin. 24;4:743-56.en_US
dc.identifier.doi10.1016/j.nicl.2014.04.011
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33546
dc.identifier.urihttp://hdl.handle.net/1880/51854
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentRadiologyen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectCuprizoneen_US
dc.subjectExperimental autoimmune encephalomyelitisen_US
dc.subjectLysolecithinen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectMultiple sclerosisen_US
dc.subjectTheiler's murine encephalomyelitis virusen_US
dc.titleUnderstanding disease processes in multiple sclerosis through magnetic resonance imaging studies in animal modelsen_US
dc.typejournal article
thesis.degree.disciplineRadiology / Physiology / Clinical Neurosciences
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