MicroRNA Response Elements-Mediated miRNA-miRNA Interactions in Prostate Cancer
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2012-11-04
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Abstract
The cell is a highly organized system of interacting molecules including proteins, mRNAs, and miRNAs. Analyzing the cellfrom a systems perspective by integrating different types of data helps revealing the complexity of diseases. Although there isemerging evidence that microRNAs have a functional role in cancer, the role of microRNAs in mediating cancer progressionand metastasis remains not fully explored. As the amount of available miRNA and mRNA gene expression data grows, moresystematic methods combining gene expression and biological networks become necessary to explore miRNA function. In this workI integrated functional miRNA-target interactions with mRNA and miRNA expression to infer mRNA-mediated miRNA-miRNAinteractions. The inferred network represents miRNA modulation through common targets. The network is used to characterizethe functional role of microRNA response element (MRE) to mediate interactions between miRNAs targeting the MRE. Resultsrevealed that miRNA-1 is a key player in regulating prostate cancer progression. 11 miRNAs were identified as diagnostic andprognostic biomarkers that act as tumor suppressor miRNAs. This work demonstrates the utility of a network analysis as opposedto differential expression to find important miRNAs that regulate prostate cancer.
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Mohammed Alshalalfa, “MicroRNA Response Elements-Mediated miRNA-miRNA Interactions in Prostate Cancer,” Advances in Bioinformatics, vol. 2012, Article ID 839837, 10 pages, 2012. doi:10.1155/2012/839837