MicroRNA Response Elements-Mediated miRNA-miRNA Interactions in Prostate Cancer

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dc.contributor.authorAlshalalfa, Mohammed
dc.date.accessioned2018-09-27T11:53:11Z
dc.date.available2018-09-27T11:53:11Z
dc.date.issued2012-11-04
dc.date.updated2018-09-27T11:53:11Z
dc.description.abstractThe cell is a highly organized system of interacting molecules including proteins, mRNAs, and miRNAs. Analyzing the cellfrom a systems perspective by integrating different types of data helps revealing the complexity of diseases. Although there isemerging evidence that microRNAs have a functional role in cancer, the role of microRNAs in mediating cancer progressionand metastasis remains not fully explored. As the amount of available miRNA and mRNA gene expression data grows, moresystematic methods combining gene expression and biological networks become necessary to explore miRNA function. In this workI integrated functional miRNA-target interactions with mRNA and miRNA expression to infer mRNA-mediated miRNA-miRNAinteractions. The inferred network represents miRNA modulation through common targets. The network is used to characterizethe functional role of microRNA response element (MRE) to mediate interactions between miRNAs targeting the MRE. Resultsrevealed that miRNA-1 is a key player in regulating prostate cancer progression. 11 miRNAs were identified as diagnostic andprognostic biomarkers that act as tumor suppressor miRNAs. This work demonstrates the utility of a network analysis as opposedto differential expression to find important miRNAs that regulate prostate cancer.
dc.description.versionPeer Reviewed
dc.identifier.citationMohammed Alshalalfa, “MicroRNA Response Elements-Mediated miRNA-miRNA Interactions in Prostate Cancer,” Advances in Bioinformatics, vol. 2012, Article ID 839837, 10 pages, 2012. doi:10.1155/2012/839837
dc.identifier.doihttps://doi.org/10.1155/2012/839837
dc.identifier.urihttp://hdl.handle.net/1880/108369
dc.language.rfc3066en
dc.rights.holderCopyright © 2012 Mohammed Alshalalfa. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleMicroRNA Response Elements-Mediated miRNA-miRNA Interactions in Prostate Cancer
dc.typeJournal Article
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